Investigating the effects of e-cigarette use on blood vessel health

MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers

['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10688286

This study is looking at how vaping just once can affect your blood vessels and inflammation, and it's for both e-cigarette users and traditional smokers, so we can better understand the short-term health effects of vaping.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF PENNSYLVANIA (nih funded)
Locations1 site (PHILADELPHIA, UNITED STATES)
Trial IDNIH-10688286 on ClinicalTrials.gov

What this research studies

This research examines how a single episode of vaping affects blood vessel function and inflammation in both e-cigarette users and traditional cigarette smokers. Using advanced MRI techniques, the study aims to measure changes in blood flow and vascular health immediately after vaping. By analyzing biological markers in the blood, the researchers hope to uncover the short-term health impacts of e-cigarette use, which are currently not well understood. Participants will undergo assessments before and after vaping to capture these physiological changes.

Who could benefit from this research

Good fit: Ideal candidates for this research include current e-cigarette users and traditional cigarette smokers who are willing to participate in physiological assessments.

Not a fit: Patients who do not use e-cigarettes or traditional cigarettes may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide critical insights into the health risks associated with e-cigarette use, potentially leading to better public health recommendations.

How similar studies have performed: Other research has indicated that vaping can have immediate adverse effects on vascular health, suggesting that this study builds on existing findings.

Where this research is happening

PHILADELPHIA, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Conditions: Atherosclerotic Cardiovascular Disease, atherosclerotic disease, atherosclerotic vascular disease

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.