Investigating the effects of a medication on heart health in patients with repaired aorta narrowing
Official title: Clinical benefits and mechanism of action of angiotensin-II receptor blocker on Cardiovascular remodeling in patients with repaired coarctation of aorta
Funded at Mayo Clinic Rochester · NIH-10914234 · Data updated 2026-11-12
This study is looking at how a specific heart medication can help improve heart function in adults who have had surgery for a condition called aortic coarctation, especially for those with slightly high blood pressure, by checking how well their hearts work before and after taking the medication.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 25, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $652,072 |
| NIH project number | 5R01HL162830-02 |
| Project ID | NIH-10914234 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with a history of repaired aortic coarctation who are experiencing borderline or stage 1 hypertension.
✕Less likely to help
Patients without a history of aortic coarctation or those with normal blood pressure may not benefit from this research.
What this research studies
This research focuses on understanding how angiotensin-II receptor blockers can improve heart function in adults who have had surgery for aortic coarctation. The study will assess the medication's impact on heart remodeling and overall cardiovascular health, particularly in patients experiencing borderline hypertension. Participants will undergo evaluations to measure heart performance and blood flow before and after treatment, helping to clarify the medication's benefits and mechanisms of action.
Why it matters
Potential benefit: If successful, this research could lead to improved heart health and reduced risk of heart failure for patients with repaired aortic coarctation.
How similar studies have gone: Previous research has shown that angiotensin-II receptor blockers can improve cardiovascular outcomes in similar patient populations, indicating a promising avenue for this investigation.
Where this research is happening
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Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Egbe, Alexander — Mayo Clinic Rochester
- Study coordinator: Egbe, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.