Investigating the causes of lung transplant complications
Official title: Complementary pathways of necroptosis in recipient and donor lung tissue that drive primary lung allograft dysfunction
Funded at Northwestern University at Chicago · NIH-10996663 · Data updated 2026-11-12
This study is looking at how certain immune cells and signals in the lungs can cause problems after a lung transplant, especially for people who have had lung injuries before, with the goal of finding new ways to help these patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $799,354 |
| NIH project number | 1R01HL173940-01A1 |
| Project ID | NIH-10996663 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals undergoing lung transplantation, particularly those with a history of acute lung injuries or acute respiratory distress syndrome.
✕Less likely to help
Patients who are not candidates for lung transplantation or those without pre-existing lung conditions may not benefit from this research.
What this research studies
This research focuses on understanding primary graft dysfunction (PGD), a serious complication that affects many lung transplant recipients, especially those with prior lung injuries. The study examines the role of specific immune cells and molecular signals in both the donor and recipient lungs that contribute to PGD. By exploring how these processes lead to lung injury, the research aims to identify potential therapeutic targets to improve outcomes for lung transplant patients. The methodology includes analyzing immune responses and cellular mechanisms in lung tissues.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing primary graft dysfunction in lung transplant patients, enhancing their survival and quality of life.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in lung transplantation, suggesting that this approach could yield significant insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Bharat, Ankit — Northwestern University at Chicago
- Study coordinator: Bharat, Ankit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.