Investigating the causes of dry eye disease related to autoimmune responses
Pathobiology of autoimmune Meibomian gland dysfunction
This study is looking at how problems with the glands that help keep your eyes moist can make dry eye symptoms worse, especially for people with autoimmune conditions like Sjögren Syndrome, and it hopes to find new ways to help treat these issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10992534 on NIH RePORTER |
What this research studies
This research focuses on understanding the underlying mechanisms of dry eye disease (DED), particularly in patients with autoimmune conditions like Sjögren Syndrome. It aims to explore how dysfunction in the Meibomian glands, which are crucial for maintaining tear film stability, contributes to the symptoms of DED. By studying the immune responses in these glands, the research seeks to identify potential triggers and pathways that lead to increased inflammation and damage. Patients with DED may benefit from insights gained through this research, which could lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dry eye disease, especially those with autoimmune disorders like Sjögren Syndrome.
Not a fit: Patients without dry eye disease or those not affected by autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from dry eye disease, particularly those with autoimmune conditions.
How similar studies have performed: Previous research has shown promising results in understanding autoimmune responses in other conditions, suggesting potential for success in this area as well.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: De Paiva, Cintia S. — Baylor College of Medicine
- Study coordinator: De Paiva, Cintia S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.