Investigating the causes and treatments of Acute Respiratory Distress Syndrome, pneumonia, and sepsis.
Official title: Great Lakes Clinical Center of the Acute Respiratory Distress Syndrome, Pneumonia and Sepsis (APS) Consortium
Funded at University of Michigan at Ann Arbor · NIH-11085978 · Data updated 2026-11-12
This study is looking at how Acute Respiratory Distress Syndrome (ARDS), pneumonia, and sepsis are connected, and it aims to help at least 1,000 patients by collecting health information and samples to find better, personalized treatments for these serious conditions over the next six years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $547,174 |
| NIH project number | 5U01HL168308-03 |
| Project ID | NIH-11085978 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with Acute Respiratory Distress Syndrome, pneumonia, or sepsis.
✕Less likely to help
Patients with chronic respiratory conditions unrelated to ARDS, pneumonia, or sepsis may not benefit from this research.
What this research studies
This research focuses on understanding the complex relationships between Acute Respiratory Distress Syndrome (ARDS), pneumonia, and sepsis, which are serious health conditions that often occur together. The study will enroll at least 1,000 patients over six years, collecting clinical data and biological samples such as blood and swabs to analyze the different characteristics of these conditions. By examining these samples and data, researchers aim to identify specific patient profiles that could lead to more effective treatments tailored to individual needs. Patients will be followed up at multiple time points to gather long-term health information.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and outcomes for patients suffering from ARDS, pneumonia, and sepsis.
How similar studies have gone: Previous research has shown promise in understanding ARDS and related conditions, but this approach aims to deepen insights into their biological diversity, making it a novel endeavor.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Hyzy, Robert C — University of Michigan at Ann Arbor
- Study coordinator: Hyzy, Robert C
Related research
Other NIH-funded projects on the same topics.
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Great Lakes ARDS, Pneumonia & Sepsis Patient Registry Network
A large multi-hospital effort will enroll and deeply profile adults with ARDS, pneumonia, or sepsis to understand why these conditions vary so much and to guide better trials and treatments.
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Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
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Endothelial inflammation memory after sepsis and pneumonia
A scientist is studying how blood vessel cells “remember” sepsis and why survivors get worse when they catch pneumonia, with the goal of finding better ways to reduce organ damage.
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Identifying ARDS patients who may benefit from paralytics guided by high-frequency clinical data
This grant aims to help doctors figure out which adults with ARDS are most likely to benefit from paralytic medications using detailed bedside data and electronic health records.
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Resilience endotypes and early ARDS detection using biomarkers and AI
A Duke University team is using biomarkers and smart data analysis to detect ARDS early and uncover patterns that predict how patients recover.
-
PAR1’s role in lung lymphatics and a new therapy approach for ARDS
This grant explores how the thrombin receptor PAR1 affects lung lymphatics to understand and ultimately reduce lung injury in ARDS patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.