Investigating the cancer extracellular matrix for new treatment targets
Enhanced mass-spectrometry-based approaches for in-depth profiling of the cancer extracellular matrix
This study is looking at the supportive structure around tumors to find new proteins that could help us understand cancer better and improve treatments for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10903967 on NIH RePORTER |
What this research studies
This research focuses on understanding the cancer extracellular matrix (ECM), a complex structure that supports tumor growth and progression. By using advanced mass-spectrometry techniques, the project aims to identify various proteins and their modifications within the ECM that could serve as new biomarkers or therapeutic targets. Patients may benefit from this research as it seeks to uncover vulnerabilities in cancer that could lead to improved treatment strategies. The study involves analyzing the ECM's composition and its role in cancer biology, which could ultimately enhance patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with advanced cancer who are seeking new treatment options.
Not a fit: Patients with early-stage cancer or those not diagnosed with cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the discovery of new biomarkers and treatment targets for cancer, potentially improving patient survival rates.
How similar studies have performed: Previous research has shown promise in utilizing mass-spectrometry techniques to analyze the ECM, indicating that this approach could yield valuable insights into cancer treatment.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Naba, Alexandra — University of Illinois at Chicago
- Study coordinator: Naba, Alexandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.