Investigating stem-like T cells in multiple sclerosis
Official title: Stem-like T cells as bioindicators and orchestrators of the disease process in MS and animal models
Funded at Saint Louis University · NIH-11125029 · Data updated 2026-11-12
This study is looking at special immune cells in people with multiple sclerosis to see how they might be involved in the disease, with the hope of finding new ways to help manage MS in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 12, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $305,000 |
| NIH project number | 1R56AI180725-01A1 |
| Project ID | NIH-11125029 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals diagnosed with multiple sclerosis or those exhibiting related autoimmune symptoms.
✕Less likely to help
Patients with non-autoimmune neurological conditions may not receive any benefit from this research.
What this research studies
This research focuses on understanding how certain immune cells, specifically stem-like CD4+ T cells, contribute to the autoimmune responses seen in multiple sclerosis (MS). By studying these cells in both animal models and human samples, the research aims to identify specific characteristics that could serve as biomarkers for the disease. The project will utilize advanced analytical tools to better define these cells and their roles in disease progression, potentially leading to new therapeutic targets. Patients may benefit from insights gained about the immune mechanisms involved in MS.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients with multiple sclerosis.
How similar studies have gone: While the investigation of CD4+ T cells in MS is ongoing, the specific focus on stem-like CD4+ T cells as biomarkers is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Hawiger, Daniel — Saint Louis University
- Study coordinator: Hawiger, Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.