Investigating small RNAs and their role in rheumatoid arthritis risk
Small RNAs and risk of rheumatoid arthritis
This study is looking at how tiny molecules in your blood might help us understand who is more likely to develop rheumatoid arthritis, and how the bacteria in your gut could play a role, with the hope of finding ways to prevent the disease before it starts.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11073047 on NIH RePORTER |
What this research studies
This research focuses on understanding how small RNAs, which are important gene regulators, may influence the development of rheumatoid arthritis (RA). By analyzing blood samples from individuals, the study aims to identify specific biomarkers that can predict who is at a higher risk of developing RA. The research will also explore how changes in the microbiome may affect these biomarkers and contribute to the disease. Ultimately, the goal is to enable early interventions that could prevent the onset of RA and reduce disability in at-risk individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of rheumatoid arthritis or those showing early signs of autoimmune conditions.
Not a fit: Patients who are already diagnosed with advanced rheumatoid arthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the identification of biomarkers that allow for early treatment of rheumatoid arthritis, potentially preventing the disease and improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using biomarkers for early detection of autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Nashville, United States
- Veterans Health Administration — Nashville, United States (Active)
Researchers
- Principal investigator: Ormseth, Michelle Jane — Veterans Health Administration
- Study coordinator: Ormseth, Michelle Jane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.