Investigating sleep patterns to understand aging and Alzheimer's disease
Sleep Spindle Dynamics as a Clinical Biomarker of Aging, Alzheimer's Disease, and Trisomy 21
['FUNDING_OTHER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10733629
This study is looking at how certain brain wave patterns during sleep, called sleep spindles, can help us understand aging and conditions like Alzheimer's and Down syndrome, with the goal of creating better ways to diagnose these issues for people of all ages.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10733629 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how sleep spindles, which are specific brain wave patterns during sleep, can serve as biomarkers for aging and conditions like Alzheimer's disease and trisomy 21. By analyzing sleep data from a diverse group of participants across various ages, the study aims to identify the variability in these sleep patterns and their relationship to different neurological disorders. The researchers will develop a mathematical framework to better characterize these sleep spindle dynamics, which could lead to more precise diagnostic tools for these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals of varying ages who may be experiencing symptoms of Alzheimer's disease, trisomy 21, or other neurodegenerative disorders.
Not a fit: Patients who do not have any neurological or psychiatric conditions related to sleep dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods for Alzheimer's disease and related conditions, enhancing early detection and treatment options.
How similar studies have performed: Previous research has shown promise in using sleep biomarkers for diagnosing neurological conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PRERAU, MICHAEL J — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: PRERAU, MICHAEL J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Mental disorders