Investigating sex-based differences in glioblastoma using advanced animal models
Incorporation of the Four Core Genotype Transgenic Animal and a Newly Developed EGFRvIII-Based GBM Model into the existing Program Project Grant on Sex-Based Differences in Glioma
This study is looking at how being male or female might change the way glioblastoma, a serious brain tumor, behaves and responds to treatment, with the hope of finding better, more personalized treatment options for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10916680 on NIH RePORTER |
What this research studies
This research focuses on understanding how sex differences affect glioblastoma, the most common type of malignant brain tumor. By utilizing advanced animal models that incorporate specific genetic mutations, researchers aim to explore the biological mechanisms behind these differences, particularly in immune responses. The study will analyze how these factors contribute to the varying incidence and prognosis of glioblastoma in males and females. Patients may benefit from insights that could lead to more tailored and effective treatments based on sex.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma, particularly those who are male or female and may exhibit different responses to treatment.
Not a fit: Patients with glioblastoma who do not have significant sex-based differences in their disease presentation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for glioblastoma that consider sex-based biological differences.
How similar studies have performed: Previous research has shown promising results in understanding sex differences in various cancers, suggesting that this approach may yield valuable insights.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Lathia, Justin D. — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Lathia, Justin D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.