Investigating severe forms of major depression across Nordic countries
A Trans-Nordic Study of Extreme Major Depression
This study is looking at people with severe depression to find out why some don’t respond to treatment and how their genetics might play a role, all with the goal of helping improve care for those who are really struggling.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10823226 on NIH RePORTER |
What this research studies
This research focuses on understanding extreme major depressive disorder (MDD), which affects individuals with the most severe symptoms and poor outcomes. By analyzing a large population over several years, the study aims to identify individuals who experience treatment resistance and significant disability. The research will utilize advanced genetic analysis to explore inherited risk factors associated with extreme MDD. This comprehensive approach seeks to improve clinical predictions and treatment strategies for those suffering from the most debilitating forms of depression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing extreme major depressive disorder, particularly those with treatment-resistant symptoms.
Not a fit: Patients with mild to moderate depression or those not experiencing significant impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and interventions for individuals with severe major depression.
How similar studies have performed: Previous research has shown promise in identifying genetic factors associated with major depression, but this study's focus on extreme cases is a novel approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Sullivan, Patrick F — Univ of North Carolina Chapel Hill
- Study coordinator: Sullivan, Patrick F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.