Investigating RNA modifications in the nervous system
Official title: Epitranscriptomic regulation in the mammalian nervous system
Funded at University of Pennsylvania · NIH-10893664 · Data updated 2026-11-12
This study is looking at how changes in RNA can influence the growth and function of the brain, which could help us understand and improve treatments for brain disorders that affect people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | December 23, 2024 |
| Project end | November 30, 2032 |
| Funding year | 2025 |
| Award (this year) | $985,026 |
| NIH project number | 1R35NS137480-01 |
| Project ID | NIH-10893664 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with developmental, neurological, psychiatric, or degenerative brain disorders.
✕Less likely to help
Patients with conditions unrelated to RNA modifications or those outside the age range of 21+ years may not receive benefit from this research.
What this research studies
This research explores how various RNA modifications affect the development and function of the mammalian nervous system. By utilizing advanced techniques such as human induced pluripotent stem cell-derived brain organoids, the study aims to uncover the roles of these modifications in brain disorders. The research will involve both mouse models and human brain organoids to better understand the implications of epitranscriptomic regulation. Patients may benefit from insights gained into the mechanisms underlying neurological and psychiatric conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating brain disorders linked to RNA modification dysregulation.
How similar studies have gone: Other research has shown promising results in understanding RNA modifications, particularly in the context of mRNA vaccines, indicating potential for success in this area.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Ming, Guo-Li — University of Pennsylvania
- Study coordinator: Ming, Guo-Li
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.