Investigating premature vascular aging using a lab model
"Clinical Trials" on a Premature Vascular Aging-on-a-Chip Model
['FUNDING_OTHER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10896333
This study is creating a special model to help understand how aging affects blood vessels in kids with Hutchinson-Gilford progeria syndrome, so we can find better treatments for heart-related issues they might face.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10896333 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a biomimetic model to study premature vascular aging, particularly in patients with Hutchinson-Gilford progeria syndrome (HGPS). By creating a microfluidic system that mimics blood vessels, researchers aim to understand how aging affects the cardiovascular system and to test potential treatments. The model will utilize patient-derived cells to replicate the conditions of HGPS, allowing for more relevant clinical trial designs. This innovative approach could lead to better insights into cardiovascular diseases associated with aging.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Hutchinson-Gilford progeria syndrome or those experiencing premature vascular aging.
Not a fit: Patients without any cardiovascular issues or those not affected by premature aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients suffering from premature vascular aging and related cardiovascular conditions.
How similar studies have performed: Previous research has shown promise in using biomimetic models to study vascular conditions, indicating that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, Y. SHRIKE — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: ZHANG, Y. SHRIKE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease