Investigating post-traumatic epilepsy using large animal models
Large Animal Core (Core 1)
This study is looking at how the brain reacts to epilepsy after an injury by using pigs, so researchers can watch and understand what happens in real-time, which could help improve treatments for people with epilepsy in the future.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11088156 on NIH RePORTER |
What this research studies
This research focuses on developing a large animal model of post-traumatic epilepsy using swine, which allows for advanced monitoring and imaging techniques. The team will implant devices for video EEG monitoring and perform surgeries to study the brain's response to epilepsy. By using cutting-edge technology, they aim to visualize cellular processes in real-time, providing insights into the mechanisms of epilepsy. The research also includes the collection and archiving of biological data to support future studies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced traumatic brain injuries and are at risk of developing epilepsy.
Not a fit: Patients who do not have a history of traumatic brain injury or epilepsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from post-traumatic epilepsy.
How similar studies have performed: Previous research has shown success in using animal models to study epilepsy, indicating that this approach has potential for valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Costine-Bartell, Beth a — Massachusetts General Hospital
- Study coordinator: Costine-Bartell, Beth a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.