Investigating pancreatic-immune organoid models for type 1 diabetes
Official title: Advanced pancreatic-immune organoid models of type 1 diabetes subtypes and therapeutic responses
Funded at Yale University · NIH-11059434 · Data updated 2026-11-12
This study is looking at tiny lab-grown versions of the pancreas to learn more about type 1 diabetes and how certain treatments, like teplizumab, can work better for people with the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,201,988 |
| NIH project number | 1UG3DK142189-01 |
| Project ID | NIH-11059434 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with new onset type 1 diabetes or those at risk of developing the condition.
✕Less likely to help
Patients with type 2 diabetes or other non-autoimmune forms of diabetes may not benefit from this research.
What this research studies
This research focuses on understanding type 1 diabetes (T1D) by examining pancreatic organoids derived from induced pluripotent stem cells. The study aims to identify specific features of beta cells that influence the progression of T1D and the effectiveness of immune therapies, such as teplizumab. By utilizing advanced robotic cell culture systems, researchers will minimize technical variations and better detect subtle disease characteristics and responses to treatments. This approach could lead to improved strategies for managing T1D and tailoring therapies to individual patient needs.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for type 1 diabetes, potentially improving patient outcomes and quality of life.
How similar studies have gone: Previous research has shown promise in using organoid models to study diabetes, indicating that this approach may yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Herold, Kevan C — Yale University
- Study coordinator: Herold, Kevan C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.