Investigating new imaging and treatment methods for aortic valve calcification
Official title: Molecular imaging and therapy in aortic valve calcification
Funded at VA Connecticut Healthcare System · NIH-10951529 · Data updated 2026-11-12
This study is looking at a heart condition called calcific aortic valve disease, especially in older adults and veterans, to find new ways to see how it develops and discover possible new treatments to help prevent it from getting worse.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Connecticut Healthcare System NIH-funded |
| Lab location | 1 site (West Haven, United States) |
| Project start | October 1, 2023 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX006089-02 |
| Project ID | NIH-10951529 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with calcific aortic valve disease, particularly older adults and veterans.
✕Less likely to help
Patients with non-calcific aortic valve conditions or those who are not experiencing significant symptoms may not benefit from this research.
What this research studies
This research focuses on calcific aortic valve disease (CAVD), which is a common cause of aortic stenosis affecting many individuals, particularly older adults and veterans. The project aims to develop a novel molecular imaging approach to better understand the biological processes involved in CAVD and to identify potential new therapies. By using advanced imaging techniques and gene expression profiling, researchers hope to track changes in the aortic valve and evaluate new therapeutic agents that could prevent the progression of this disease.
Why it matters
Potential benefit: If successful, this research could lead to new medical therapies that effectively treat or prevent the progression of aortic valve calcification, reducing the need for surgical interventions.
How similar studies have gone: While there have been efforts to develop therapies for CAVD, this approach utilizing molecular imaging and targeting specific biological processes is relatively novel and has not been extensively tested.
Where this research is happening
-
VA Connecticut Healthcare System
West Haven, United States Active
Researchers
- Principal investigator: Sadeghi, Mehran M — VA Connecticut Healthcare System
- Study coordinator: Sadeghi, Mehran M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.