Investigating new cell types involved in blood vessel diseases
Novel vascular smooth muscle cell progenitors in development and disease
This study is looking at how certain cells in your blood vessels behave when there's not enough oxygen, which could help us understand and find better treatments for heart and lung diseases like atherosclerosis and pulmonary hypertension.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10875628 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of smooth muscle cell progenitors in the development of vascular diseases such as atherosclerosis and pulmonary hypertension. By studying how these progenitor cells behave in response to conditions like hypoxia, the researchers aim to uncover the mechanisms that lead to excessive smooth muscle cell accumulation in blood vessels. The approach involves using animal models to track the behavior of these cells and their interactions with other cell types in the vascular system. This could provide insights into potential therapeutic targets for treating vascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with atherosclerosis or pulmonary hypertension, particularly those experiencing severe symptoms.
Not a fit: Patients with non-vascular related diseases or those without significant vascular complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse vascular diseases, improving patient outcomes.
How similar studies have performed: Other research has shown promising results in understanding the role of progenitor cells in vascular diseases, indicating that this approach has potential for success.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Greif, Daniel — Yale University
- Study coordinator: Greif, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.