Investigating mutations in a brain receptor linked to neurological symptoms.
Official title: Disease-Associated Mutations and Ligand Activation of the Adhesion G Protein-Coupled Receptor ADGRB2
Funded at Emory University · NIH-10811019 · Data updated 2026-11-12
This study is looking at how certain changes in a brain receptor might cause movement problems in people with spastic paraparesis, and it aims to find new ways to help those affected by these issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $430,375 |
| NIH project number | 1R21NS133638-01A1 |
| Project ID | NIH-10811019 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with spastic paraparesis or other neurological symptoms associated with mutations in the ADGRB2 receptor.
✕Less likely to help
Patients without mutations in the ADGRB2 receptor or those not exhibiting neurological symptoms may not benefit from this research.
What this research studies
This research focuses on understanding how specific mutations in the ADGRB2 receptor, which is primarily found in the central nervous system, affect its function and contribute to neurological conditions like spastic paraparesis. By studying both human patients with these mutations and specially designed mice, the researchers aim to uncover the mechanisms behind these mutations and their impact on motor function. Additionally, they will explore a potential ligand that may influence the receptor's activity, which could lead to new insights into treatment options for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for patients with neurological disorders linked to ADGRB2 mutations.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown promise in understanding G protein-coupled receptors and their role in neurological disorders.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Hall, Randy a. — Emory University
- Study coordinator: Hall, Randy a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.