Investigating metabolism in critical illnesses like sepsis and ARDS
Official title: Translational Metabolomics in Critical Care
Funded at University of Michigan at Ann Arbor · NIH-11011375 · Data updated 2026-11-12
This study is looking at how the body changes during serious illnesses like sepsis and ARDS to find helpful markers that can predict how patients will do and improve their treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 1, 2020 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $438,672 |
| NIH project number | 2R35GM136312-06 |
| Project ID | NIH-11011375 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with sepsis or ARDS who are experiencing severe metabolic disturbances.
✕Less likely to help
Patients with mild respiratory issues or those not diagnosed with sepsis or ARDS may not benefit from this research.
What this research studies
This research focuses on understanding the metabolic changes that occur during critical illnesses such as sepsis and Acute Respiratory Distress Syndrome (ARDS). By using advanced techniques in Translational Metabolomics, the study aims to identify biomarkers that can help predict patient outcomes and guide treatment. The research employs innovative animal models and clinical cohorts to validate findings, utilizing state-of-the-art analytical methods to analyze biological samples. This approach seeks to bridge the gap between laboratory discoveries and clinical applications, ultimately improving patient care.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for patients suffering from sepsis and ARDS.
How similar studies have gone: Previous research has shown promise in using metabolomics to identify biomarkers in critical illnesses, indicating that this approach has potential for success.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Stringer, Kathleen a — University of Michigan at Ann Arbor
- Study coordinator: Stringer, Kathleen a
Related research
Other NIH-funded projects on the same topics.
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Metabolic testing to improve care for sepsis and ARDS
This work uses blood metabolic testing to find patterns that could help doctors predict outcomes and tailor care for adults with sepsis and ARDS.
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Newborn screening: using gene and metabolite data to refine true vs false positives
A study using genetic and metabolomic data from newborn blood spots to better distinguish real metabolic disorders from false alarms.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
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Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
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Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
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Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.