Investigating melatonin's protective effects against kidney injury caused by antibiotics
Mechanistic evaluation of melatonin as a protectant against antibiotic associated kidney injury
This study is looking at how melatonin, a natural hormone, might help protect your kidneys from damage caused by antibiotics, and it's for anyone who is concerned about kidney health while taking these medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11055983 on NIH RePORTER |
What this research studies
This research explores how melatonin, a natural hormone with antioxidant properties, may help protect the kidneys from damage caused by antibiotics. The study aims to understand the mechanisms behind antibiotic-associated acute kidney injury (AKI) and how melatonin can mitigate these effects. By conducting laboratory experiments on human kidney cells exposed to harmful antibiotics, researchers will assess melatonin's ability to activate protective pathways and restore cellular function. This could lead to new strategies for preventing kidney damage in patients receiving antibiotic treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include hospitalized patients who are prescribed antibiotics and are at risk for acute kidney injury.
Not a fit: Patients who are not receiving antibiotics or those with pre-existing severe kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of kidney injury in patients treated with antibiotics.
How similar studies have performed: Previous research has shown promising results for the use of melatonin in protecting against various forms of kidney injury, suggesting potential success for this approach.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Brunetti, Luigi — Rutgers Biomedical and Health Sciences
- Study coordinator: Brunetti, Luigi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.