Investigating lung problems caused by collagen mutations in bone disorders
Official title: Lung developmental defects caused by type I collagen mutations in mouse models of osteogenesis imperfecta
Funded at Univ of Arkansas for Med Scis · NIH-10912793 · Data updated 2026-11-12
This study is looking at how changes in certain collagen genes can cause breathing problems in people with osteogenesis imperfecta and similar bone conditions, using mice to see how these gene changes affect both bone shape and lung health, with the hope of finding better treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $380,760 |
| NIH project number | 5R01HL166748-02 |
| Project ID | NIH-10912793 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with osteogenesis imperfecta or other skeletal dysplasias that affect lung function.
✕Less likely to help
Patients without skeletal dysplasias or those whose respiratory issues are unrelated to collagen mutations may not benefit from this research.
What this research studies
This research explores how mutations in collagen genes, specifically COL1A1 and COL1A2, lead to respiratory issues in patients with osteogenesis imperfecta (OI) and other skeletal dysplasias. By using mouse models, the study examines the relationship between skeletal deformities and lung function, focusing on how these mutations affect lung development and respiratory mechanics. The researchers aim to understand the underlying mechanisms of lung dysfunction associated with these genetic conditions, which could inform future therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for respiratory complications in patients with osteogenesis imperfecta and similar conditions.
How similar studies have gone: Previous research has shown promising results in understanding the impact of collagen mutations on lung function, indicating that this approach could yield valuable insights.
Where this research is happening
-
Univ of Arkansas for Med Scis
Little Rock, United States Active
Researchers
- Principal investigator: Morello, Roy — Univ of Arkansas for Med Scis
- Study coordinator: Morello, Roy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.