Investigating lung issues in sheep with a genetic disorder affecting bone metabolism
Official title: Respiratory Distress in Sheep with Hypophosphatasia: Etiology, Functional Consequences and Rescue
Funded at Texas A&m Agrilife Research · NIH-10790694 · Data updated 2026-11-12
This study is looking at how a genetic disorder called hypophosphatasia impacts lung growth and breathing in sheep, which could help us learn more about similar issues in people with this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m Agrilife Research NIH-funded |
| Lab location | 1 site (College Station, UNITED STATES) |
| Project start | August 19, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $223,105 |
| NIH project number | 1R21HD114076-01 |
| Project ID | NIH-10790694 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with hypophosphatasia or those with related respiratory issues stemming from genetic disorders.
✕Less likely to help
Patients without hypophosphatasia or those not experiencing respiratory complications may not benefit from this research.
What this research studies
This research focuses on understanding how a genetic disorder called hypophosphatasia affects lung development and function in sheep. By creating a sheep model with a specific gene mutation, the researchers aim to explore the origins of respiratory distress and other complications associated with this condition. The study will involve examining the lung pathology in these sheep at various stages of development to uncover the underlying mechanisms that lead to respiratory problems. This research could provide valuable insights that may eventually translate to better understanding and treatment of similar conditions in humans.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for respiratory complications in patients with hypophosphatasia and similar disorders.
How similar studies have gone: While this research utilizes a novel sheep model, similar studies in other animal models have shown promise in understanding genetic disorders and their effects on lung function.
Where this research is happening
-
Texas A&m Agrilife Research
College Station, United States Active
Researchers
- Principal investigator: Gaddy, Dana — Texas A&m Agrilife Research
- Study coordinator: Gaddy, Dana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.