Investigating inhibitors of serotonin N-acetyltransferase for circadian rhythm disorders
Serotonin N-Acetyl-Transferase Inhibitors for Circadian Rhythm Disorders
This study is looking at how problems with our body’s natural clock can impact mental health conditions like bipolar disorder and seasonal affective disorder, and it aims to find new ways to help by targeting a specific enzyme involved in melatonin production.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Kearney NIH-funded |
| Lab location | 1 site (Kearney, United States) |
| Project ID | NIH-10522741 on NIH RePORTER |
What this research studies
This research focuses on understanding how circadian rhythm dysregulation affects mental health disorders like bipolar disorder and seasonal affective disorder. It aims to identify new inhibitors of the enzyme serotonin-N-acetyltransferase (SNAT), which plays a crucial role in melatonin synthesis. By using advanced virtual screening techniques, the researchers will look for compounds that can effectively inhibit SNAT, potentially leading to new treatments for mood disorders. The study will also explore the structure of SNAT to improve the effectiveness of these inhibitors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with bipolar disorder, major depressive disorder, or seasonal affective disorder.
Not a fit: Patients with circadian rhythm disorders not related to mood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for patients suffering from mood disorders linked to circadian rhythm disruptions.
How similar studies have performed: While the approach of targeting SNAT for mood disorders is innovative, previous studies have shown promise in related areas, indicating potential for success.
Where this research is happening
Kearney, United States
- University of Nebraska Kearney — Kearney, United States (Active)
Researchers
- Principal investigator: Thomas, Allen — University of Nebraska Kearney
- Study coordinator: Thomas, Allen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.