Investigating inflammatory stem cell variants in cystic fibrosis
Pro-Inflammatory Stem Cell Variants in Cystic Fibrosis
This study is looking at how inflammation affects people with cystic fibrosis, even when there are no bacterial infections, by checking lung samples to find specific stem cells that might make the inflammation worse, with the hope of discovering new ways to help improve lung health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11019672 on NIH RePORTER |
What this research studies
This research explores the role of inflammation in cystic fibrosis (CF) and how it may persist independently of bacterial infections. It examines the presence of pro-inflammatory stem cell variants in the lungs of CF patients, which could contribute to disease progression. By analyzing lung samples, the study aims to identify these variants and understand their impact on inflammation and lung function. The findings could lead to new therapeutic strategies that target these inflammatory processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cystic fibrosis, particularly those experiencing chronic lung inflammation.
Not a fit: Patients without cystic fibrosis or those whose lung inflammation is not related to the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that better manage inflammation in cystic fibrosis patients.
How similar studies have performed: Similar research has shown promising results in understanding inflammation in chronic obstructive pulmonary disease, suggesting potential for success in this area as well.
Where this research is happening
Houston, United States
- University of Houston — Houston, United States (Active)
Researchers
- Principal investigator: Mckeon, Frank D. — University of Houston
- Study coordinator: Mckeon, Frank D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.