Investigating immune defense cells in the kidneys related to urinary tract infections.
Official title: Human Genetic Approach for UTI Points to Novel Immune Defense Cells of the Kidney Epithelia
Funded at Columbia University Health Sciences · NIH-10985094 · Data updated 2026-11-12
This study is looking at how our genes might affect how our bodies fight off urinary tract infections (UTIs), especially for those who get them often, to help create better ways to diagnose and treat these infections.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $153,540 |
| NIH project number | 1K01DK135917-01A1 |
| Project ID | NIH-10985094 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of recurrent urinary tract infections or those at high risk for developing such infections.
✕Less likely to help
Patients who do not experience urinary tract infections or have no genetic predisposition to them may not benefit from this research.
What this research studies
This research focuses on understanding how genetic factors influence the immune response to urinary tract infections (UTIs), which are common and often recurrent. By conducting genome-wide association studies, the team aims to identify specific genetic variants that increase the risk of UTIs. They will also explore the roles of certain genes in immune defense within the bladder and kidneys using advanced techniques like RNA sequencing and mouse models. The goal is to develop better diagnostic tools and personalized treatment strategies for patients at risk of recurrent UTIs.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for patients suffering from recurrent urinary tract infections.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to UTIs, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Xu, Katherine — Columbia University Health Sciences
- Study coordinator: Xu, Katherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.