Investigating immune changes in glioblastoma during treatment and progression
Official title: Understanding the cellular and functional changes in the immune tumor microenvironment of glioblastoma during progression and treatments.
Funded at Beth Israel Deaconess Medical Center · NIH-11061308 · Data updated 2026-11-12
This study is looking at how glioblastoma, a tough type of brain cancer, affects the immune system around it as the cancer grows and responds to treatments, with the hope of finding new ways to help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 17, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $648,380 |
| NIH project number | 5R01CA271601-03 |
| Project ID | NIH-11061308 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who are undergoing standard treatments or are in the progression phase of their disease.
✕Less likely to help
Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research focuses on glioblastoma, a challenging brain cancer, by examining how the immune environment around the tumor changes as the disease progresses and in response to treatments. Researchers will analyze the cellular makeup of the tumor and its interactions with immune cells, using advanced techniques like single-cell RNA sequencing. The goal is to better understand the immunosuppressive nature of glioblastoma and identify potential targets for new therapies that could improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, potentially improving survival rates and quality of life for patients.
How similar studies have gone: While glioblastoma presents unique challenges, similar research approaches have shown promise in understanding tumor-immune interactions in other cancers, indicating potential for success in this area as well.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Charest, Alain — Beth Israel Deaconess Medical Center
- Study coordinator: Charest, Alain
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CD38-Driven Changes in Brain Tumor Metabolism and Immunity in Glioblastoma
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.