Investigating immune cells involved in Type 1 Diabetes
Official title: Autoimmune Stem-like CD8 T cells in Type 1 Diabetes
Funded at Sloan-Kettering Inst Can Research · NIH-11083737 · Data updated 2026-11-12
This study is looking at how specific immune cells called CD8 T cells might play a role in causing Type 1 Diabetes, using a mouse model to learn more about how these cells behave in the pancreas, with the hope of finding new ways to help manage or treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 8, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $867,074 |
| NIH project number | 5R01AI173249-03 |
| Project ID | NIH-11083737 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 1 Diabetes or those at risk of developing the condition.
✕Less likely to help
Patients with Type 2 Diabetes or other non-autoimmune forms of diabetes may not benefit from this research.
What this research studies
This research focuses on understanding how certain immune cells, specifically CD8 T cells, contribute to the development of Type 1 Diabetes (T1D). By using a mouse model that mimics human T1D, the researchers aim to uncover the origins and behaviors of these autoimmune T cells in the pancreas. They will utilize advanced imaging and sequencing techniques to explore the interactions and signals within the immune system that sustain these harmful cells. The ultimate goal is to identify potential therapeutic strategies to intervene in the disease process.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse the autoimmune destruction of insulin-producing cells in Type 1 Diabetes.
How similar studies have gone: Previous research has shown promising results in understanding autoimmune mechanisms in other conditions, suggesting potential for success in this area as well.
Where this research is happening
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Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Schietinger, Andrea — Sloan-Kettering Inst Can Research
- Study coordinator: Schietinger, Andrea
Related research
Other NIH-funded projects on the same topics.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
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This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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How the pancreas environment affects insulin-producing cells in type 1 diabetes
Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.