Investigating immune cells involved in Type 1 Diabetes
Autoimmune Stem-like CD8 T cells in Type 1 Diabetes
This study is looking at how specific immune cells called CD8 T cells might play a role in causing Type 1 Diabetes, using a mouse model to learn more about how these cells behave in the pancreas, with the hope of finding new ways to help manage or treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11083737 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain immune cells, specifically CD8 T cells, contribute to the development of Type 1 Diabetes (T1D). By using a mouse model that mimics human T1D, the researchers aim to uncover the origins and behaviors of these autoimmune T cells in the pancreas. They will utilize advanced imaging and sequencing techniques to explore the interactions and signals within the immune system that sustain these harmful cells. The ultimate goal is to identify potential therapeutic strategies to intervene in the disease process.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Type 1 Diabetes or those at risk of developing the condition.
Not a fit: Patients with Type 2 Diabetes or other non-autoimmune forms of diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse the autoimmune destruction of insulin-producing cells in Type 1 Diabetes.
How similar studies have performed: Previous research has shown promising results in understanding autoimmune mechanisms in other conditions, suggesting potential for success in this area as well.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Schietinger, Andrea — Sloan-Kettering Inst Can Research
- Study coordinator: Schietinger, Andrea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.