Investigating immune cells in human skin using advanced imaging techniques
Official title: In vivo label free optical imaging of immune cells in human skin
Funded at University of California-Irvine · NIH-10793631 · Data updated 2026-11-12
This study is looking at how immune cells work together in human skin to help us better understand and treat conditions like cancer and autoimmune diseases, using advanced imaging technology to see these cells in action without any labels.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | March 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $201,023 |
| NIH project number | 5R21AR082648-02 |
| Project ID | NIH-10793631 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with skin cancers or autoimmune disorders who are seeking innovative treatment options.
✕Less likely to help
Patients with non-skin-related conditions or those who do not have immune system involvement may not benefit from this research.
What this research studies
This research focuses on understanding how immune cells interact in human skin, which is crucial for addressing diseases like cancer and autoimmune disorders. The team will use a cutting-edge imaging technology called intravital multiphoton microscopy (MPM) to visualize immune cells without the need for labels, allowing for real-time observation of their behavior in a natural environment. By capturing detailed 3D images of skin, the study aims to identify different immune cell populations and their roles in disease processes. This approach is particularly important as it overcomes the limitations of previous studies conducted in animal models, which do not accurately reflect human immune responses.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of skin-related diseases, including cancers and autoimmune conditions.
How similar studies have gone: Previous research using similar imaging techniques has shown promise in understanding immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Balu, Mihaela — University of California-Irvine
- Study coordinator: Balu, Mihaela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.