Investigating immune cell similarities between humans and mice
Human and mouse transcriptome profiling identifies cross-species homology of mononuclear phagocytes
This study is looking at how certain immune cells work in humans and mice to help us better understand our body's defenses against infections, which could lead to new treatments for various health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10984470 on NIH RePORTER |
What this research studies
This research focuses on understanding the mononuclear phagocyte system, which is crucial for both innate and adaptive immunity. By comparing immune cells from human and mouse tissues, the study aims to identify similarities and differences in how these cells function across species. The researchers will collect fresh tissue samples from various organs and use advanced sequencing techniques to analyze gene expression and cellular functions. This approach could enhance our understanding of immune responses to infections and inform the development of new therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to immune responses, such as infections or autoimmune disorders.
Not a fit: Patients with stable, non-immune related conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for various infectious diseases.
How similar studies have performed: Previous research has shown promise in understanding immune cell functions across species, suggesting that this approach could yield valuable insights.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Jakubzick, Claudia V — Dartmouth College
- Study coordinator: Jakubzick, Claudia V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.