Investigating human circadian disorders using a new cell-based platform
A novel cell-based platform to study human circadian disorders
This study is looking at how changes in certain genes that control our body clocks can affect sleep problems, and it's using a new method to test these changes in human cells, which could help people with sleep disorders understand their condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project ID | NIH-10912812 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic mutations in clock genes affect circadian rhythms and sleep disorders. By developing a novel cell-based platform, researchers aim to study the functionality of specific genetic variations in human cells rather than using traditional animal models. This approach allows for more efficient testing of how these mutations impact biological processes related to sleep. Patients with circadian rhythm disorders may benefit from insights gained through this innovative methodology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with known genetic mutations affecting their circadian rhythms or those experiencing sleep disorders.
Not a fit: Patients without genetic mutations related to circadian rhythms or those not experiencing sleep-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from circadian rhythm disorders.
How similar studies have performed: Other research has shown success in using cell-based models to study genetic disorders, indicating that this approach has potential for meaningful insights.
Where this research is happening
Tallahassee, United States
- Florida State University — Tallahassee, United States (Active)
Researchers
- Principal investigator: Lee, Choogon — Florida State University
- Study coordinator: Lee, Choogon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.