Investigating human circadian disorders using a new cell-based platform
Official title: A novel cell-based platform to study human circadian disorders
Funded at Florida State University · NIH-10912812 · Data updated 2026-11-12
This study is looking at how changes in certain genes that control our body clocks can affect sleep problems, and it's using a new method to test these changes in human cells, which could help people with sleep disorders understand their condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | August 23, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $308,000 |
| NIH project number | 5R01GM147340-02 |
| Project ID | NIH-10912812 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with known genetic mutations affecting their circadian rhythms or those experiencing sleep disorders.
✕Less likely to help
Patients without genetic mutations related to circadian rhythms or those not experiencing sleep-related issues may not benefit from this research.
What this research studies
This research focuses on understanding how genetic mutations in clock genes affect circadian rhythms and sleep disorders. By developing a novel cell-based platform, researchers aim to study the functionality of specific genetic variations in human cells rather than using traditional animal models. This approach allows for more efficient testing of how these mutations impact biological processes related to sleep. Patients with circadian rhythm disorders may benefit from insights gained through this innovative methodology.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from circadian rhythm disorders.
How similar studies have gone: Other research has shown success in using cell-based models to study genetic disorders, indicating that this approach has potential for meaningful insights.
Where this research is happening
-
Florida State University
Tallahassee, United States Active
Researchers
- Principal investigator: Lee, Choogon — Florida State University
- Study coordinator: Lee, Choogon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.