Investigating how zinc affects Group B Streptococcus colonization and biofilm formation
Defining the impact of zinc on Streptococcus agalactiae biofilm and colonization
['FUNDING_CAREER'] · UNIVERSITY OF LOUISVILLE · NIH-10782521
This study is looking at how zinc might affect the way Group B Streptococcus (GBS) bacteria grow and stick around during pregnancy, with the goal of finding ways to help reduce the risk of infections for expectant moms.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF LOUISVILLE (nih funded) |
| Locations | 1 site (LOUISVILLE, UNITED STATES) |
| Trial ID | NIH-10782521 on ClinicalTrials.gov |
What this research studies
This research explores the role of zinc in the colonization of Group B Streptococcus (GBS) during pregnancy. It aims to understand how zinc influences the production of biofilm by GBS, which is a protective layer that helps the bacteria persist in the reproductive tract. The study will utilize various methods, including genetic analysis and in vitro models, to assess how zinc availability affects GBS behavior and its interaction with human tissues. By examining these factors, the research seeks to uncover potential strategies to reduce the risk of infections associated with GBS colonization in pregnant women.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who are at risk of Group B Streptococcus colonization.
Not a fit: Patients who are not pregnant or those who do not carry Group B Streptococcus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for infections caused by Group B Streptococcus during pregnancy.
How similar studies have performed: Previous research has indicated that zinc plays a significant role in bacterial behavior, suggesting that this approach may yield valuable insights.
Where this research is happening
LOUISVILLE, UNITED STATES
- UNIVERSITY OF LOUISVILLE — LOUISVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOSTER, RYAN S — UNIVERSITY OF LOUISVILLE
- Study coordinator: DOSTER, RYAN S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections, Infectious Disease Pathway, Infectious Diseases