Investigating how viral infections cause chronic inflammation in the placenta
Viral pathogenesis of chronic inflammatory lesions of the placenta
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10893993
This study is looking at how viral infections might cause long-lasting inflammation in the placenta, which can lead to early births and growth issues in babies, and it’s for pregnant women who want to help researchers understand these problems better to improve health for moms and their little ones.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10893993 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of viral infections in causing chronic inflammation in the placenta, which is linked to preterm birth and growth restrictions in infants. Researchers will analyze placental tissue from pregnant women to identify viral infections and inflammatory responses associated with chronic placental inflammation. Additionally, maternal blood samples will be tested to find signals that could predict the development of this inflammation. The study aims to uncover the mechanisms behind these conditions to improve maternal and infant health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women experiencing complications such as preterm birth or intrauterine growth restriction.
Not a fit: Patients who are not pregnant or those without complications related to preterm birth or placental inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for preterm birth and related complications.
How similar studies have performed: Previous research has shown that understanding the role of infections in pregnancy can lead to significant advancements in maternal and child health, suggesting this approach has potential for success.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WYLIE, KRISTINE M. — WASHINGTON UNIVERSITY
- Study coordinator: WYLIE, KRISTINE M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections