Investigating how viral and immune factors affect HPV-related cancers in people living with HIV.
Official title: Project 1: Exploring viral and immunological factors of HPV associated cancers in PLWH and its relation to survival
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-10898558 · Data updated 2026-11-12
This study is looking into why people with HIV are more likely to get certain cancers caused by HPV, like anal and cervical cancers, especially in countries with fewer resources, and it hopes to find better ways to prevent and treat these cancers for those living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | August 3, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $142,342 |
| NIH project number | 5U54CA277834-02 |
| Project ID | NIH-10898558 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are at risk for HPV-related cancers.
✕Less likely to help
Patients who do not have HIV or are not at risk for HPV-related cancers may not benefit from this research.
What this research studies
This research focuses on understanding why people living with HIV (PLWH) have a higher incidence of cancers caused by the human papillomavirus (HPV), such as anal and cervical cancers. It aims to explore the immune and viral factors that contribute to these disparities, particularly in low- and middle-income countries. By examining the tumor environment and immune responses, the study seeks to identify better prevention and treatment strategies for HPV-related cancers in PLWH. The findings could lead to improved screening and therapeutic approaches tailored for this vulnerable population.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention and treatment options for HPV-related cancers in people living with HIV.
How similar studies have gone: While there is limited research specifically targeting HPV-related cancers in PLWH, similar studies in cancer immunotherapy have shown promising results, indicating potential for success in this area.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Botha, Matthys Hendrik — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Botha, Matthys Hendrik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.