Investigating how venous cells can help heal lung damage from viral infections
Pulmonary Vascular Regeneration via Venous Endothelial Progenitors
This study is looking at how the blood vessels in the lungs can heal after being hurt by serious viral infections like the flu, and it hopes to find new ways to help people with breathing problems like acute respiratory distress syndrome (ARDS).
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10916484 on NIH RePORTER |
What this research studies
This research focuses on understanding how the lung's blood vessels can regenerate after damage caused by severe respiratory viral infections, such as influenza. It explores the role of venous endothelial progenitor cells in repairing the lung's microvasculature, which is crucial for proper gas exchange. By using advanced techniques like clonal lineage tracing and transplantation, the study aims to identify the mechanisms that drive endothelial repair in response to injury. Patients may benefit from insights gained about potential new therapies for acute respiratory distress syndrome (ARDS).
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced severe respiratory viral infections and are at risk for developing acute respiratory distress syndrome.
Not a fit: Patients with chronic lung diseases unrelated to viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung repair and improve outcomes for patients suffering from acute respiratory distress syndrome.
How similar studies have performed: Other research has shown promise in using progenitor cells for tissue regeneration, suggesting that this approach may yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Wong, Joanna — University of Pennsylvania
- Study coordinator: Wong, Joanna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.