Investigating how two receptors respond to a key immune signaling molecule
It's a tug of war: structure, consequences, and inhibition of CXCR4 and ACKR3 responses to lymphocyte chemoattractant CXCL12
This study is looking at how certain receptors in your body, called CXCR4 and ACKR3, work with a signaling molecule to help your immune system and organ development, with the goal of creating better treatments for autoimmune diseases that could help you manage your condition more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11051789 on NIH RePORTER |
What this research studies
This research focuses on the roles of the CXCR4 and ACKR3 receptors in immune responses and organ development, particularly how they interact with the signaling molecule CXCL12. The study aims to develop better therapeutic compounds that can effectively target these receptors, which are implicated in various inflammatory and autoimmune diseases. By understanding the mechanisms of these receptors, the research seeks to improve treatment options for conditions where these pathways are disrupted. Patients may benefit from new therapies that enhance or inhibit these receptors to better manage their autoimmune conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from autoimmune diseases or inflammatory conditions that may be influenced by CXCR4 and ACKR3 signaling.
Not a fit: Patients with conditions unrelated to immune responses or those not affected by CXCR4 or ACKR3 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases and other inflammatory conditions.
How similar studies have performed: Previous research has shown promise in targeting similar receptors for therapeutic purposes, indicating potential for success in this area.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Handel, Tracy M — University of California, San Diego
- Study coordinator: Handel, Tracy M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.