Investigating how to improve fertility using somatic cell techniques
Official title: Reconstructing Somatic Chromosomes
Funded at Oregon Health & Science University · NIH-10936533 · Data updated 2026-11-12
This study is looking at a new way to help women with infertility by using a special technique to change the genetic material in eggs that are stuck in a certain stage of development, to see if this can help them get ready for fertilization.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | September 26, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $648,606 |
| NIH project number | 5R01HD113562-02 |
| Project ID | NIH-10936533 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals or couples experiencing infertility related to chromosomal abnormalities.
✕Less likely to help
Patients with infertility not related to chromosomal issues may not benefit from this research.
What this research studies
This research explores the use of somatic cell nuclear transfer (SCNT) to replace the chromosomes in oocytes that are arrested in metaphase. By introducing diploid chromatin from somatic cells, the study aims to understand how these modified oocytes can form meiotic spindles and potentially lead to successful fertilization. The researchers will investigate whether inducing DNA double strand breaks can promote homolog pairing and recombination in these oocytes, which could pave the way for new infertility treatments.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic options for individuals facing infertility due to chromosomal issues.
How similar studies have gone: Preliminary studies have shown promise in using similar techniques, indicating potential for success in this novel approach.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Mitalipov, Shoukhrat — Oregon Health & Science University
- Study coordinator: Mitalipov, Shoukhrat
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.