Investigating how to improve fertility using somatic cell techniques
Reconstructing Somatic Chromosomes
This study is looking at a new way to help women with infertility by using a special technique to change the genetic material in eggs that are stuck in a certain stage of development, to see if this can help them get ready for fertilization.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10936533 on NIH RePORTER |
What this research studies
This research explores the use of somatic cell nuclear transfer (SCNT) to replace the chromosomes in oocytes that are arrested in metaphase. By introducing diploid chromatin from somatic cells, the study aims to understand how these modified oocytes can form meiotic spindles and potentially lead to successful fertilization. The researchers will investigate whether inducing DNA double strand breaks can promote homolog pairing and recombination in these oocytes, which could pave the way for new infertility treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals or couples experiencing infertility related to chromosomal abnormalities.
Not a fit: Patients with infertility not related to chromosomal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic options for individuals facing infertility due to chromosomal issues.
How similar studies have performed: Preliminary studies have shown promise in using similar techniques, indicating potential for success in this novel approach.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Mitalipov, Shoukhrat — Oregon Health & Science University
- Study coordinator: Mitalipov, Shoukhrat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.