Investigating how to help human pancreatic beta cells grow and regenerate
Epigenetic regulation in therapeutic human pancreatic beta cell proliferation
This study is looking at how certain changes in our genes can help the cells in the pancreas that make insulin grow back, which could lead to new treatments for people with diabetes.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10756443 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of epigenetics in the replication of human pancreatic beta cells, which are crucial for insulin production. By identifying new pathways and potential drug targets, the project aims to develop innovative therapies that could enhance the regeneration of these cells in patients with diabetes. The research involves advanced techniques such as single-cell RNA sequencing and chromatin conformation capture to analyze cellular behavior at a molecular level. Patients may benefit from new treatment options that could improve their diabetes management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Type 1 diabetes who may benefit from therapies aimed at regenerating pancreatic beta cells.
Not a fit: Patients with Type 2 diabetes or those whose diabetes is not related to beta cell dysfunction may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking therapies that promote the regeneration of insulin-producing beta cells, potentially transforming diabetes treatment.
How similar studies have performed: While the exploration of epigenetic regulation in beta cell proliferation is a relatively novel approach, similar studies have shown promise in understanding cellular regeneration in other contexts.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Karakose-Balioglu, Esra — Icahn School of Medicine at Mount Sinai
- Study coordinator: Karakose-Balioglu, Esra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.