Investigating how TMX1 protein affects blood clotting
Official title: The Transmembrane Protein Disulfide Isomerase TMX1 Negatively Regulates Thrombosis
Funded at Temple Univ of the Commonwealth · NIH-11011322 · Data updated 2026-11-12
This study is looking at a protein called TMX1 to see how it helps control blood clotting and platelet function, which could lead to better treatments for people with conditions like heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 15, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $621,245 |
| NIH project number | 5R01HL162845-03 |
| Project ID | NIH-11011322 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of acute coronary syndrome or other thrombotic conditions.
✕Less likely to help
Patients who do not have issues related to blood clotting or thrombosis may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of the TMX1 protein in regulating blood clotting and platelet function. It aims to explore how TMX1 acts as a negative regulator of platelet activation and coagulation, which is crucial in conditions like acute coronary syndrome. The study will involve characterizing the mechanisms by which TMX1 influences these processes, potentially leading to new therapeutic strategies for managing thrombosis. Patients may benefit from insights gained about how to better control blood clotting in various medical conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients at risk of thrombosis, reducing complications from conditions like acute coronary syndrome.
How similar studies have gone: Previous research has shown success in targeting platelet activation and coagulation pathways, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Essex, David W — Temple Univ of the Commonwealth
- Study coordinator: Essex, David W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.