Investigating how tissue kallikrein affects kidney injury in children with STEC-HUS
Official title: Role of tissue kallikrein in alternative complement pathway activation in STEC-HUS
Funded at Baylor College of Medicine · NIH-11098738 · Data updated 2026-11-12
This study is looking at how a specific protein might affect kidney problems in children with a serious condition caused by a bacterial infection, and it aims to find new ways to help these kids feel better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $200,625 |
| NIH project number | 5R21AI175828-02 |
| Project ID | NIH-11098738 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who have been diagnosed with STEC-HUS.
✕Less likely to help
Patients who are adults or those without a diagnosis of STEC-HUS may not benefit from this research.
What this research studies
This research focuses on understanding the role of tissue kallikrein in the activation of the alternative complement pathway in children suffering from Shiga toxin-associated hemolytic uremic syndrome (STEC-HUS). The study aims to explore how this pathway contributes to kidney injury following infection with a specific type of bacteria. By examining the biological mechanisms involved, researchers hope to identify potential therapeutic targets that could improve outcomes for affected patients. The research will involve laboratory analyses and possibly clinical observations to gather data on the condition's progression and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for children suffering from STEC-HUS, potentially reducing kidney damage and long-term health complications.
How similar studies have gone: Previous research has shown promising results in understanding the complement pathway's role in kidney injuries, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Sartain, Sarah Elizabeth — Baylor College of Medicine
- Study coordinator: Sartain, Sarah Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.