Investigating how tissue factor affects blood clotting and immune responses
Tissue factor-dependent coagulation in thrombosis and immune responses
This study is looking at a protein called tissue factor that helps with blood clotting and immune responses, to see how unusual levels of it can cause blood clots in people with conditions like heart disease or infections, with the goal of finding new ways to help those at risk of clots.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11026369 on NIH RePORTER |
What this research studies
This research focuses on tissue factor (TF), a protein that plays a crucial role in blood clotting and immune responses. It examines how abnormal levels of TF can lead to thrombosis, particularly in conditions like atherosclerosis and infections. The study utilizes advanced assays to measure TF levels and their effects on coagulation and immune signaling pathways. By understanding these mechanisms, the research aims to identify potential biomarkers and therapeutic targets for patients at risk of thrombosis.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with atherosclerotic cardiovascular disease, those experiencing thrombosis, or individuals with bacterial infections.
Not a fit: Patients with conditions unrelated to blood coagulation or immune responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from thrombosis and related cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of tissue factor in thrombosis and immune responses, indicating that this approach is building on established findings.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Mackman, Nigel — Univ of North Carolina Chapel Hill
- Study coordinator: Mackman, Nigel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.