Investigating how tiny vesicles in the blood affect Type 1 diabetes
Circulating Extracellular Vesicles in the Pathogenesis of Type 1 Diabetes
This study is looking at tiny particles in the blood that might help us understand how Type 1 diabetes affects insulin-producing cells, with the goal of finding new ways to diagnose and treat the condition early on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10851992 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of circulating extracellular vesicles (EVs) in the development of Type 1 diabetes (T1D), an autoimmune condition that leads to the destruction of insulin-producing beta cells. The study aims to identify the molecular characteristics of these EVs and how they may contribute to beta cell dysfunction and death. By analyzing blood samples from individuals with T1D, researchers hope to uncover potential biomarkers that could aid in the early diagnosis of the disease. This approach could provide insights into the mechanisms of T1D and help develop new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Type 1 diabetes, particularly those in the early stages of the disease.
Not a fit: Patients with Type 2 diabetes or other forms of diabetes unrelated to autoimmune processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management of Type 1 diabetes through the identification of specific biomarkers.
How similar studies have performed: Previous research has shown promise in using extracellular vesicles as biomarkers in other autoimmune diseases, suggesting potential for success in this area as well.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Vasavada, Rupangi C — Beckman Research Institute/city of Hope
- Study coordinator: Vasavada, Rupangi C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.