Investigating how tiny vesicles affect immune responses in Type 1 Diabetes
Extracellular Vesicle-mediated islet immune cross talk in Type 1 Diabetes pathogenesis
This study is looking at tiny particles called extracellular vesicles that help cells talk to each other in Type 1 Diabetes, and it aims to understand how these particles from immune cells and stressed pancreatic cells affect each other, with the hope of finding new insights into the disease that could help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-11085058 on NIH RePORTER |
What this research studies
This research explores the role of extracellular vesicles (EVs) in the communication between pancreatic islets and immune cells in Type 1 Diabetes (T1D). The team will analyze how EVs derived from T1D-infiltrating T-cells and stressed islet cells influence islet health and immune cell behavior. By examining the protein content of these vesicles, the study aims to uncover mechanisms that contribute to the progression of T1D. Patients may be involved through the donation of tissue samples, which will help in understanding the disease better.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with Type 1 Diabetes or those who are positive for autoantibodies related to the disease.
Not a fit: Patients without Type 1 Diabetes or related autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of Type 1 Diabetes, potentially paving the way for innovative treatments.
How similar studies have performed: Previous research in other autoimmune diseases has shown that extracellular vesicles play a significant role in disease mechanisms, suggesting a promising avenue for this investigation.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Reijonen, Helena Kristiina — Beckman Research Institute/city of Hope
- Study coordinator: Reijonen, Helena Kristiina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.