Investigating how TIM-3 in dendritic cells affects immune responses and tolerance
Role of Tim-3:Bat-3 pathway in inducing tolerogenic DCs and peripheral tolerance
This study is looking at a protein called TIM-3 that helps control how our immune system works, especially in diseases like autoimmune disorders and cancer, by using special mice without this protein to see how it affects immune cells called T cells, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11047384 on NIH RePORTER |
What this research studies
This research explores the role of TIM-3, a protein found on dendritic cells, in regulating immune responses, particularly in autoimmune diseases and cancer. By studying genetically modified mice that lack TIM-3 in dendritic cells, researchers aim to understand how this protein influences the activation and behavior of T cells, which are crucial for immune function. The goal is to uncover mechanisms that could lead to new treatments for conditions where the immune system is either overactive or underactive.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or cancers that may benefit from improved immune regulation.
Not a fit: Patients with non-autoimmune conditions or those not affected by cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve immune tolerance in autoimmune diseases and enhance cancer immunotherapy.
How similar studies have performed: Previous research has shown promising results in targeting immune checkpoints like TIM-3 for cancer therapies, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Kuchroo, Vijay K. — Brigham and Women's Hospital
- Study coordinator: Kuchroo, Vijay K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.