Investigating how the contact activation system affects sepsis and vascular dysfunction.
Contact Activation and Infection
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-10903781
This study is looking into how a part of our immune system affects blood flow and inflammation during serious infections like sepsis, with the goal of finding new ways to help treat this condition and improve outcomes for patients in the hospital.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-10903781 on ClinicalTrials.gov |
What this research studies
This research explores the role of the contact activation system in causing vascular dysfunction and inflammatory responses during severe bacterial infections, particularly sepsis. The study aims to understand how this system contributes to complications like organ failure and poor blood circulation, despite the availability of antibiotics. By examining the molecular and cellular events triggered by specific pathogens, the research seeks to identify new therapeutic targets for treating sepsis, which remains a significant cause of morbidity and mortality in hospitals.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults experiencing severe bacterial infections or sepsis.
Not a fit: Patients with non-bacterial infections or those not experiencing sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for sepsis, improving survival rates and outcomes for affected patients.
How similar studies have performed: While the approach of targeting the contact activation system is innovative, similar research has shown promise in understanding sepsis mechanisms, indicating potential for success.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCCARTY, OWEN J — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: MCCARTY, OWEN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome