Investigating how the body interacts with gut microbes during important life processes.
New mouse models to investigate host-microbe dynamics in physiology and innate immunity
This study is looking at how our bodies keep a healthy balance of gut bacteria, especially during important times like breastfeeding, by exploring the role of certain molecules made by our gut cells, which could help us understand how to support gut health during these key life stages.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10990533 on NIH RePORTER |
What this research studies
This research focuses on understanding how the body maintains a healthy balance with gut microbes, particularly during significant physiological events like lactation. By developing new mouse models, the researchers aim to explore the role of specific antimicrobial molecules, known as alpha-defensins, produced by intestinal cells in shaping the gut microbiota. The study will examine how changes in these molecules affect the composition of gut bacteria and overall health. This could provide insights into the mechanisms that keep our gut microbiome in balance during critical life stages.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals interested in gut health, particularly those experiencing issues related to microbiota imbalance or conditions influenced by gut health.
Not a fit: Patients with no interest in gut health or those not experiencing any related health issues may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing gut health and preventing diseases related to microbiota imbalance.
How similar studies have performed: Other research has shown promising results in understanding host-microbe interactions, but this approach using innovative mouse models is relatively novel.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Bevins, Charles L — University of California at Davis
- Study coordinator: Bevins, Charles L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.