Investigating how Tfh cell metabolism affects lupus and related heart disease
Targeting Tfh Cell Metabolic Regulation in SLE and SLE-Associated Atherosclerosis
This study is looking at how certain immune cells called follicular helper T cells might affect lupus and heart health, with the goal of finding new ways to help people with lupus feel better by understanding how these cells use nutrients in their activity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10829862 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of follicular helper T cells (Tfh) in systemic lupus erythematosus (SLE) and its association with atherosclerosis, a common cardiovascular complication. The study aims to explore how the metabolism of these immune cells influences the disease process and contributes to the production of autoantibodies. By examining the metabolic pathways of Tfh cells, the researchers hope to identify new therapeutic targets that could improve treatment outcomes for patients with SLE. The approach includes analyzing how these cells utilize nutrients like glucose and glutamine during their activation and differentiation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus, particularly those experiencing cardiovascular complications.
Not a fit: Patients without a diagnosis of systemic lupus erythematosus or those not experiencing related cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the metabolic processes of immune cells in lupus, potentially reducing disease severity and improving cardiovascular health.
How similar studies have performed: While the metabolic regulation of Tfh cells is a relatively novel area of investigation, preliminary findings suggest that targeting immune cell metabolism may offer promising therapeutic avenues in autoimmune diseases.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Rathmell, Jeffrey C. — Vanderbilt University Medical Center
- Study coordinator: Rathmell, Jeffrey C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.