Investigating how TAOK2 kinase affects the development of human neural stem cells.
TAOK2 Kinase Signaling in Human Neural Stem Cell Development
This study is looking at how a gene called TAOK2, which is connected to autism, affects the growth and development of brain cells, hoping to find out how changes in this gene might play a role in autism and other related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10737612 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the TAOK2 gene, which is linked to autism spectrum disorders, in the development and function of human neural stem cells. Researchers will explore how mutations in TAOK2 affect neural progenitor cell development and differentiation, which are critical processes in brain development. By examining the signaling pathways regulated by TAOK2, the study aims to uncover mechanisms that could contribute to neurodevelopmental and psychiatric disorders. This work could provide insights into how disruptions in these processes may lead to conditions like autism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autism spectrum disorders or those with a family history of neurodevelopmental conditions.
Not a fit: Patients with neurodevelopmental disorders not associated with TAOK2 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodevelopmental and psychiatric disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic factors in neurodevelopment, but the specific focus on TAOK2 in human neural stem cells is relatively novel.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Yadav, Smita — University of Washington
- Study coordinator: Yadav, Smita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.