Investigating how T cells move and their effects on heart health during immunotherapy
T cell migration and cardiovascular toxicity in immunotherapy
This study is looking at how T cells move in the body during immunotherapy and how that movement can sometimes cause heart problems, with the goal of making these treatments safer and more effective for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11129994 on NIH RePORTER |
What this research studies
This research focuses on understanding how T cells, which are crucial for immune responses, migrate in the body and how this migration can lead to cardiovascular toxicity during immunotherapy treatments. The study aims to identify the mechanisms that control T cell movement and to develop strategies that enhance the effectiveness of T cell therapies while minimizing harmful side effects, particularly those affecting the heart. Using advanced imaging techniques and genetic screening, researchers will analyze the behavior of T cells after they are infused into patients, aiming to improve safety and efficacy in treating various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients undergoing immunotherapy for conditions like cancer, autoimmune diseases, or atherosclerosis.
Not a fit: Patients who are not receiving immunotherapy or those with pre-existing severe cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer immunotherapy treatments with fewer cardiovascular side effects for patients.
How similar studies have performed: Previous research has shown promise in understanding T cell behavior in immunotherapy, but this specific approach to mitigating cardiovascular toxicity is relatively novel.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Kim, Minsoo — University of Rochester
- Study coordinator: Kim, Minsoo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.