Investigating how T cells affect tumor growth in neurofibromatosis
T cells in neurofibroma pathogenesis and malignanttransformation
['FUNDING_CAREER'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11092750
This study is looking at how certain immune cells called T cells behave in tumors related to neurofibromatosis type 1 (NF1) to see if they can help stop benign tumors from turning into cancer, using both mouse models and samples from patients to find helpful insights.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11092750 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of T cells in the development and progression of tumors associated with neurofibromatosis type 1 (NF1). The study utilizes genetically engineered mouse models to mimic the transition from benign neurofibromas to malignant peripheral nerve sheath tumors (MPNST). By analyzing T cell behavior and characteristics within these tumors, the research aims to uncover how the immune system interacts with tumor cells and potentially prevents malignancy. Patient samples will also be examined to correlate findings in mice with human disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurofibromatosis type 1, particularly those with precancerous or malignant tumors.
Not a fit: Patients without neurofibromatosis or those with unrelated cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new immunotherapy strategies that enhance the body's ability to fight tumors in patients with neurofibromatosis.
How similar studies have performed: Previous studies have shown promising results in understanding the immune response in tumor progression, suggesting that this approach could yield valuable insights.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RHODES, STEVEN DAVID — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: RHODES, STEVEN DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Advanced Cancer, cancer immunity, cancer microenvironment, cancer predisposition