Investigating how Sur1-Trpm4 affects inflammation in brain cells during autoimmune diseases
Sur1-Trpm4 regulation of the pro-inflammatory astrocytic secretome in EAE
This study is looking at how certain channels in brain cells called astrocytes affect inflammation during a condition similar to multiple sclerosis, with the hope of finding better treatments for patients dealing with this disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10794213 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Sur1-Trpm4 channels in astrocytes, a type of brain cell, during the progression of experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. The study aims to explore how these channels influence the secretion of pro-inflammatory factors that contribute to neurodegeneration and demyelination. By targeting the overall inflammatory response of astrocytes rather than individual factors, the research seeks to identify more effective therapeutic strategies. Patients may benefit from insights that could lead to new treatments for conditions like multiple sclerosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis or related central nervous system disorders.
Not a fit: Patients with non-autoimmune neurological conditions or those not diagnosed with CNS disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that reduce inflammation and improve outcomes for patients with multiple sclerosis.
How similar studies have performed: Previous research has shown promising results in targeting inflammatory pathways in astrocytes, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Gerzanich, Vladimir — University of Maryland Baltimore
- Study coordinator: Gerzanich, Vladimir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.